Journal
POLYHEDRON
Volume 30, Issue 13, Pages 2186-2194Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2011.05.048
Keywords
Schiff base; Cu-Zn complex; Crystal structure; Urease inhibition
Categories
Funding
- National Science Foundation of China [20901036]
Ask authors/readers for more resources
A series of hetero-dinuclear Cu-II-Zn-II complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L-3, L-4 and L-5 are the deprotonated forms of N,N'-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N'-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N'-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N'-bis(salicylidene)1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 mu M. The molecular docking study of the complexes with the Helicobacter pylori urease was performed. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available