Journal
POLYHEDRON
Volume 29, Issue 2, Pages 813-822Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2009.11.002
Keywords
Quinolin-2(1H)-one; 4-Amino-1,2,4-triazole; Schiff bases; Metal(II) complexes; Biological activity; X-ray structures
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Funding
- Technological Sector Research Programme, Strand 1, under the European Social Fund
- Programme for Research in Third Level Institutes
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The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1-3). Cu(II) and Zn(II) complexes (1a-3a and 1b-3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcus aureus and Escherichia coli. (C) 2009 Elsevier Ltd. All rights reserved.
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