Journal
PLOS ONE
Volume 12, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0188879
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Funding
- Liverpool School of Tropical Medicine
- University of Warwick
- Royal Liverpool University Hospital
- National Institute of Health Research (NIHR) Health Protection Unit Emerging and Zoonotic Infections in the University of Liverpool
- Liverpool School of Tropical Medicine and Public Health England
- EPSRC [EP/M027503/1]
- Wellcome Trust [109105Z/15/A]
- EPSRC [EP/M027503/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M027503/1] Funding Source: researchfish
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Objectives New point of care diagnostics are urgently needed to reduce the over-prescription of antimicrobials for bacterial respiratory tract infection (RTI). We performed a pilot cross sectional study to assess the feasibility of gas-capillary column ion mobility spectrometer (GC-IMS), for the analysis of volatile organic compounds (VOC) in exhaled breath to diagnose bacterial RTI in hospital inpatients. Methods 71 patients were prospectively recruited from the Acute Medical Unit of the Royal Liverpool University Hospital between March and May 2016 and classified as confirmed or probable bacterial or viral RTI on the basis of microbiologic, biochemical and radiologic testing. Breath samples were collected at the patient's bedside directly into the electronic nose device, which recorded a VOC spectrum for each sample. Sparse principal component analysis and sparse logistic regression were used to develop a diagnostic model to classify VOC spectra as being caused by bacterial or non-bacterial RTI. Results Summary area under the receiver operator characteristic curve was 0.73 (95% CI 0.61 +/- 0.86), summary sensitivity and specificity were 62% (95% CI 41 +/- 80%) and 80% (95% CI 64 +/- 91%) respectively (p = 0.00147). Conclusions GC-IMS analysis of exhaled VOC for the diagnosis of bacterial RTI shows promise in this pilot study and further trials are warranted to assess this technique.
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