Journal
PLOS ONE
Volume 12, Issue 11, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0185487
Keywords
-
Categories
Funding
- National Center for Global Health and Medicine [26S-111, 26S-115]
- MEXT/JSPS KAKENHI [26290067]
- SENSHIN Medical Research Foundation
- Saw Swee Hock School of Public Health, and Life Sciences Institute from the National University of Singapore
- National Research Foundation Singapore [NRF-RF-2010-05]
- National Natural Science Foundation of China (NSFC) [91331204]
- National Science Fund for Distinguished Young Scholars [31525014]
- Program of Shanghai Subject Chief Scientist [16XD1404700]
- Grants-in-Aid for Scientific Research [17H05131, 26290067, 15K05577, 17H04123] Funding Source: KAKEN
Ask authors/readers for more resources
The contemporary Japanese populations largely consist of three genetically distinct groups Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, form one almost indistinguishable cluster. To understand fine-scale genetic structure, we applied powerful haplotype-based statistical methods to genome-wide single nucleotide polymorphism data from 1600 Japanese individuals, sampled from eight distinct regions in Japan. We then combined the Japanese data with 26 other Asian populations data to analyze the shared ancestry and genetic differentiation. We found that the Japanese could be separated into nine genetic clusters in our dataset, showing a marked concordance with geography; and that major components of ancestry profile of Japanese were from the Korean and Han Chinese clusters. We also detected and dated admixture in the Japanese. While genetic differentiation between Ryukyu and Hondo was suggested to be caused in part by positive selection, genetic differentiation among the Hondo clusters appeared to result principally from genetic drift. Notably, in Asians, we found the possibility that positive selection accentuated genetic differentiation among distant populations but attenuated genetic differentiation among close populations. These findings are significant for studies of human evolution and medical genetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available