Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release

To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing beta-cyclodextrin (beta-CD) (pHEMA/MMA/beta-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/beta-CD copolymers containing different ratios of beta-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization. The polymers had high transmittance at visible wavelengths and good biocompatibility with mouse connective tissue fibroblasts. Drug loading and release studies demonstrated that introducing beta-CD into hydrogels increased loading efficiency and achieved the sustained release of the drug. Administering beta-CD via hydrogels increased the equilibrium swelling ratio, elastic modulus and tensile strength. In addition, beta-CD increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and higher cellular adhesion to the hydrogels. In summary, pHEMA/MMA/beta-CD hydrogels show great potential as IOL biomaterials that are capable of maintaining the sustained release of anti-inflammatory drugs after cataract surgery.