Journal
JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 9, Pages 509-514Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3184/174751915X14396601175593
Keywords
highly substituted cyclohexenone; Claisen-Schmidt condensation; Michael addition; diastreoselective; multi-component reaction
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Funding
- Research Council of the University of Sistan and Baluchestan
- ERDF
- Spanish Ministerio de Economia y Competitividad [MAT2013-40950-R]
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A high efficient and convenient one-pot three-component diastreoselective synthesis of polysubstituted cyclohexenones in excellent yields has been developed through Michael addition and Claisen-Schmidt condensation of aldehydes and acetophenone with 3-oxo-N-phenylbutanamide using piperidine as an effective reagent under mild conditions within sort reaction time without using any previous activation.
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