4.8 Article

Cu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines

Journal

CHEMICAL SCIENCE
Volume 6, Issue 3, Pages 1928-1931

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03358b

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Funding

  1. National Institutes of Health [GM 64444]
  2. National Science Foundation [CHE-1401722]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Chemistry [1401722] Funding Source: National Science Foundation

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A Cu(I)-catalyzed denitrogenative transannulation reaction of pyridotriazoles with terminal alkynes en route to indolizines was developed. Compared to the previously reported Rh-catalyzed transannulation reaction, this Cu-catalyzed method features aerobic conditions and a much broader scope of pyridotriazoles and alkynes.

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