Journal
PLOS ONE
Volume 11, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0168316
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Funding
- Cattle Breeding Innovative Research Team [cxgc-ias-03]
- 12th Five-Year National Science and Technology Support Project [2011BAD28B04]
- Basic Research Fund Program
- Chinese Academy of Agricultural Sciences Fundamental Research Budget Increment Projects [2013ZL031, 2014ZL006]
- Chinese Academy of Agricultural Sciences Foundation [2014ywf-yb-4]
- Beijing Natural Science Foundation [6154032]
- National Natural Science Foundations of China [31472079, 31372294, 31402039]
- National High Technology Research and Development Program of China (863 Program) [2013AA102505-4]
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Carcass traits of beef cattle have been genetically improved to increase yield of high quality meat. Genome-wide association study (GWAS) is a powerful method to identify genetic variants associated with carcass traits. For the 770K genotyped SNPs from 1141 Chinese Simmental cattle, we used the compressed mixed linear model (CMLM) to perform a genomewide association study for knuckle, biceps and shank of beef carcass traits. Seventeen significantly associated SNPs were found, which are located on BTA6, BTA14 and BTA15. Interestingly, one pleiotropic quantitative trait nucleotide (QTN), named BovineHD1400007259 (p < 10(-8)) within the well-known gene region PLAG1-CHCHD7 on BTA14, was found to govern variation of the knuckle, biceps and shank traits. The QTN accounted for 8.6% of phenotypic variance for biceps. In addition, 16 more SNPs distributed on BTA14 were detected as being associated with the carcass traits.
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