Journal
CHEMICAL SCIENCE
Volume 6, Issue 7, Pages 4261-4266Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc00503e
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Funding
- NSF [CHE-1153159, CHE-1048804]
- Jonsson Comprehensive Cancer Center (JCCC) at UCLA
- Arnold and Mabel Beckman Foundation through a Young Investigator Award
- Direct For Mathematical & Physical Scien [1153159] Funding Source: National Science Foundation
- Division Of Chemistry [1153159] Funding Source: National Science Foundation
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We report on the successful synthesis and hyperpolarization of N-unprotected alpha-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 +/- 1.0% C-13-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.
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