Journal
CHEMICAL SCIENCE
Volume 6, Issue 2, Pages 1258-1264Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03075c
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Funding
- EPSRC [EP/H024107/1, EP/I033459/1, EP/J015156/1, EP/L0236521/1]
- University of Glasgow
- WestCHEM
- Royal Society/Wolfson Foundation
- EPSRC [EP/E062814/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I033459/1, EP/E062814/1, EP/J015156/1] Funding Source: researchfish
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A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including F-19, C-13, DEPT, 2D NMR spectroscopy (COSY, HSQC and F-19-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.
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