Journal
CHEMICAL SCIENCE
Volume 6, Issue 3, Pages 2002-2009Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03641g
Keywords
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Funding
- 973 program [2013CB93390]
- NSF China [21272196, 21305116, 91429301, 31420103910, 31330047, 31221065]
- 111 Project [B12001]
- PCSIRT
- Fundamental Research Funds for the Central Universities [2011121020]
- State Key Laboratory of Chemo/biosensing and Chemometrics [2012002]
- National Scientific and Technological Major Project [2013ZX10002-002]
- Hi-Tech Research and Development Program of China (863 program) [2012AA02A201]
- Science and Technology Foundation of Xiamen [3502Z20130027]
- National Science Foundation of China for Fostering Talents in Basic Research [J1310027]
- Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University
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Activatable molecular systems enabling precise tumor localization are valuable for complete tumor resection. Herein, we report sialic acid-capped polymeric nanovesicles encapsulating the near infrared profluorophore (pNIR@P@SA) for lysosome activation based dual modality tumor imaging. The probe features surface-anchored sialic acid for tumor targeting and a core of near infrared profluorophore (pNIR) which undergoes lysosomal acidity triggered isomerization to give optical and optoacoustic signals upon cell internalization. Imaging studies reveal high-efficiency uptake and signal activation of pNIR@P@SA in subcutaneous tumors and millimeter-sized liver tumor foci in mice. The high tumor-to-healthy organ signal contrasts and discernment of tiny liver tumors from normal liver tissues validate the potential of pNIR@P@SA for high performance optical and optoacoustic imaging guided tumor resection.
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