Journal
CHEMICAL SCIENCE
Volume 6, Issue 11, Pages 6355-6360Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc02126j
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Funding
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21325206, 21172006]
- National Young Top-notch Talent Support Program
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A novel direct transformation of aliphatic terminal alkynes to alkenyl nitriles through the incorporation of a nitrogen atom into the simple hydrocarbons has been reported. The usage of inexpensive copper catalyst, O-2 as the sole oxidant, broad substrate scope as well as feasibility for late-stage modification make this protocol very promising. Mechanistic studies including DFT calculation demonstrate a novel 1,2-hydride shift process for this novel nitrogenation reaction.
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