Journal
CHEMICAL SCIENCE
Volume 6, Issue 8, Pages 4752-4755Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc01595b
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Funding
- University of Pennsylvania
- National Science Foundation
- National Institutes of Health including HRMS [NIH RR-023444]
- MALDI-MS [NSF MRI-0820996]
- NIH through the Chemistry-Biology Interface Training Program [T32 GM07133]
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Nucleic acid three-way junctions (3WJs) play key roles in biological processes such as nucleic acid replication in addition to being implicated as dynamic transient intermediates in trinucleotide repeat sequences. Structural modulation of specific nucleic acid junctions could allow for control of biological processes and disease states at the nucleic acid level. Trinucleotide repeat expansions are associated with several neurodegenerative diseases where dynamic slippage is thought to occur during replication, forming transient 3WJ intermediates with the complementary strand. Here, we report triptycene-based molecules that bind to a d(CAG).(CTG) repeat using a gel shift assay, fluorescence-quenching and circular dichroism.
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