Journal
PLOS ONE
Volume 11, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0151589
Keywords
-
Categories
Funding
- Australian Research Council [DP0985433, DP140100803]
- National Health and Medical Research Council of Australia/CIRM [APP1053621]
- Victoria/CIRM Joint Project [RMI-01739]
- Department of Industry, Commonwealth of Australia [AISRF06680]
- Australian Research Council's Future Fellowships [FT110100341]
- Monash Micro Imaging
- Monash University Centre for Electron Microscopy
- Australian Research Council [DP0985433, FT110100341] Funding Source: Australian Research Council
Ask authors/readers for more resources
Electroactive materials have been investigated as next-generation neuronal tissue engineering scaffolds to enhance neuronal regeneration and functional recovery after brain injury. Graphene, an emerging neuronal scaffold material with charge transfer properties, has shown promising results for neuronal cell survival and differentiation in vitro. In this in vivo work, electrospun microfiber scaffolds coated with self-assembled colloidal graphene, were implanted into the striatum or into the subventricular zone of adult rats. Microglia and astrocyte activation levels were suppressed with graphene functionalization. In addition, self-assembled graphene implants prevented glial scarring in the brain 7 weeks following implantation. Astrocyte guidance within the scaffold and redirection of neuroblasts from the subventricular zone along the implants was also demonstrated. These findings provide new functional evidence for the potential use of graphene scaffolds as a therapeutic platform to support central nervous system regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available