Journal
PLOS ONE
Volume 11, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0151287
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Funding
- Natural Science Foundation of Zhejiang Province of China [LY16H160048]
- Wenzhou Public Welfare Science and Technology Project [Y20140707]
- Incubation Project of The First Affiliated Hospital of Wenzhou Medical University [FHY2014009]
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In addition to protein-coding genes, the human genome makes a large amount of noncoding RNAs. Long non-coding RNAs (lncRNAs) have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. In recent years, lncRNAs have been considered to be the key regulators of tumor behavior. In this study, based on previous research, we investigated the expression and biological role of a newly identified cancerrelated lncRNA, lncRNA-uc002kmd.1. We analyzed the relationship between lncRNAuc002kmd.1 and colorectal cancer (CRC) in a total 45 CRC and paired adjacent, non-tumor tissue samples. We found that lncRNA-uc002kmd. 1 expression was usually highly expressed in carcinoma compared with the tissue adjacent to the carcinoma. Through a series of experiments, the results showed that lncRNA-uc002kmd. 1 regulates CD44 as a molecular decoy for miR211-3p. Our data indicated that the overexpression of lncRNAuc002kmd.1 enhanced cell proliferation in CRC.
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