4.6 Article

Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Insulin/receptor binding: The last piece of the puzzle?

Pierre De Meyts

BIOESSAYS (2015)

Article Biochemistry & Molecular Biology

Aromatic Anchor at an Invariant Hormone-Receptor Interface FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN

Vijay Pandyarajan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Protective hinge in insulin opens to enable its receptor engagement

John G. Menting et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

Lenka Zakova et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2014)

Article Biochemistry & Molecular Biology

Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

Lenka Zakova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

How insulin engages its primary binding site on the insulin receptor

John G. Menting et al.

NATURE (2013)

Review Biochemistry & Molecular Biology

All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element

Harish Vashisth et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

Colin W. Ward et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2012)

Article Multidisciplinary Sciences

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

Jonathan Whittaker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Brian J. Smith et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

Jiri Jiracek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Correction Biochemistry & Molecular Biology

Docking of insulin to a structurally equilibrated insulin receptor ectodomain (vol 78, pg 1531, 2010)

Harish Vashisth et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)

Review Chemistry, Multidisciplinary

CHARMM: The Biomolecular Simulation Program

B. R. Brooks et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Importance of the solvent-exposed residues of the insulin B chain α-helix for receptor binding

Tine Glendorf et al.

BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites

Linda Whittaker et al.

BIOCHEMISTRY (2008)

Article Biochemical Research Methods

On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths

Christoph Mueller-Dieckmann et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2007)

Article Multidisciplinary Sciences

Structure of the insulin receptor ectodomain reveals a folded-over conformation

Neil M. McKern et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Protein flexibility: Multiple molecular dynamics simulations of insulin chain B

FS Legge et al.

BIOPHYSICAL CHEMISTRY (2006)

Review Chemistry, Multidisciplinary

Scalable molecular dynamics with NAMD

JC Phillips et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Insulinand its receptor: structure, function and evolution

P De Meyts

BIOESSAYS (2004)

Review Biotechnology & Applied Microbiology

Structural biology of insulin and IGF1 receptors: Implications for drug design

P De Meyts et al.

NATURE REVIEWS DRUG DISCOVERY (2002)