Journal
PLOS ONE
Volume 10, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0144293
Keywords
-
Categories
Funding
- Guangdong Province, Leadership grant
- National Natural Science Foundation of China [81272452, 21102020, 21272043]
- National Cancer Institute [P30-CA072720]
Ask authors/readers for more resources
alpha-Tomatine is a glycoalkaloid found in tomatoes and curcumin is a major yellow pigment of turmeric. In the present study, the combined effect of these two compounds on prostate cancer cells was studied. Treatment of different prostate cancer cells with curcumin or alpha-tomatine alone resulted in growth inhibition and apoptosis in a concentration-dependent manner. Combinations of alpha-tomatine and curcumin synergistically inhibited the growth and induced apoptosis in prostate cancer PC-3 cells. Effects of the alpha-tomatine and curcumin combination were associated with synergistic inhibition of NF-kappa B activity and a potent decrease in the expression of its downstream gene Bcl-2 in the cells. Moreover, strong decreases in the levels of phospho-Akt and phosphor-ERK1/2 were found in PC-3 cells treated with alpha-tomatine and curcumin in combination. In animal experiment, SCID mice with PC-3 xenograft tumors were treated with alpha-tomatine and curcumin. Combination of alpha-tomatine and curcumin more potently inhibited the growth of PC-3 tumors than either agent alone. Results from the present study indicate that alpha-tomatine in combination with curcumin may be an effective strategy for inhibiting the growth of prostate cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available