Journal
PLOS ONE
Volume 10, Issue 7, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0132689
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Funding
- CONICET [PIP 0021]
- National Agency for Scientific and Technological Promotion (Agencia Nacional de Promocion Cientifica y Tecnologica)
- FONCyT [PICT 2010-1468]
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The Baeyer-Villiger Monooxygenases (BVMOs) are enzymes belonging to the Class B of flavin monooxygenases and are capable of performing exquisite selective oxidations. These enzymes have been studied from a biotechnological perspective, but their physiological substrates and functional roles are widely unknown. Here, we investigated the origin, taxonomic distribution and evolutionary history of the BVMO genes. By using in silico approaches, 98 BVMO encoding genes were detected in the three domains of life: Archaea, Bacteria and Eukarya. We found evidence for the presence of these genes in Metazoa (Hydra vulgaris, Oikopleura dioica and Adineta vaga) and Haptophyta (Emiliania huxleyi) for the first time. Furthermore, a search for other Class B monooxygenases (flavoprotein monooxygenases-FMOs - and N-hydroxylating monooxygenases - NMOs) was conducted. These sequences were also found in the three domains of life. Phylogenetic analyses of all Class B monooxygenases revealed that NMOs and BVMOs are monophyletic, whereas FMOs form a paraphyletic group. Based on these results, we propose that BVMO genes were already present in the last universal common ancestor (LUCA) and their current taxonomic distribution is the result of differential duplication and loss of paralogous genes.
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