Journal
ASIAN JOURNAL OF ANDROLOGY
Volume 17, Issue 6, Pages 942-947Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1008-682X.150253
Keywords
fertilization; hypothalamic-pituitary-gonadal axis; insulin resistance; leptin; peroxisome proliferator-activated receptor gamma; sperm physiology; spermatogenesis; spermatozoa
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Funding
- National Natural Science Foundation of China (NSFC) [81372772]
- Scientific Research Foundation for Jiangsu [(2012) 34]
- Department of Education in Jiangsu Province, China
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), China
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Peroxisome proliferator-activated receptor gamma (PPAR) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPAR acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPAR protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPAR signaling in regulating sperm energy dissipation. PPAR protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPAR signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.
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