Journal
PLOS ONE
Volume 10, Issue 5, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0127262
Keywords
-
Categories
Funding
- University of Buenos Aires, Argentina [20020100101002]
- Institute of Infection Immunology (Twincore, Hannover, Germany)
- Institute of Infection Immunology (Twincore, Hannover, Germany) [PROALAR DA/10/05]
- Laboratorio de Modulacion de la Respuesta Inmune, (IDEHU, CONICET-UBA, Argentina) [PROALAR DA/10/05]
- Ministry of Science, Technology and Productive Innovation (MINCyT, Argentina)
- German Academic Exchange Service (DAAD, Germany)
Ask authors/readers for more resources
Probiotics can modulate the immune system, conferring beneficial effects on the host. Understanding how these microorganisms contribute to improve the health status is still a challenge. Previously, we have demonstrated that Enterococcus faecalis CECT7121 implants itself and persists in the murine gastrointestinal tract, and enhances and skews the profile of cytokines towards the Th1 phenotype in several biological models. Given the importance of dendritic cells (DCs) in the orchestration of immunity, the aim of this work was to elucidate the influence of E. faecalis CECT7121 on DCs and the outcome of the immune responses. In this work we show that E. faecalis CECT7121 induces a strong dose-dependent activation of DCs and secretion of high levels of IL-12, IL-6, TNF alpha, and IL-10. This stimulation is dependent on TLR signaling, and skews the activation of T cells towards the production of IFN gamma. The influence of this activation in the establishment of Th responses in vivo shows the accumulation of specific IFN gamma-producing cells. Our findings indicate that the activation exerted by E. faecalis CECT7121 on DCs and its consequence on the cellular adaptive immune response may have broad therapeutic implications in immunomodulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available