Journal
PLOS ONE
Volume 10, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0127396
Keywords
-
Categories
Funding
- Appel a Projet Interne (API) of the University Hospital of Strasbourg
- Alsace Alzheimer 67
- Fondation Universite de Strasbourg and famille Jean Amrhein
- Projet Hospitalier de Recherche Clinique (PHRC) [IDRCB 2012-A00992-41]
- Newcastle Healthcare Charity [BH0070250]
- Academy of Medical Sciences, Wellcome Trust [BH090112]
- Wellcome Intermediate Clinical Fellowship [BH083281]
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease
- Newcastle University
- NIHR Dementia Biomedical Research Unit at Cambridge University Hospitals NHS Foundation Trust
- University of Cambridge
- Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust
- National Institute for Health Research [NF-SI-0611-10048] Funding Source: researchfish
Ask authors/readers for more resources
Objectives To assess and compare cortical thickness (CTh) of patients with prodromal Dementia with Lewy bodies (pro-DLB), prodromal Alzheimer's disease (pro-AD), DLB dementia (DLB-d), AD dementia (AD-d) and normal ageing. Methods Study participants(28 pro-DLB, 27 pro-AD, 31 DLB-d, 54 AD-d and 33 elderly controls) underwent 3Tesla T1 3D MRI and detailed clinical and cognitive assessments. We used Free-Surfer analysis package to measure CTh and investigate patterns of cortical thinning across groups. Results Comparison of CTh between pro-DLB and pro-AD (p<0.05, FDR corrected) showed more right anterior insula thinning in pro-DLB, and more bilateral parietal lobe and left parahippocampal gyri thinning in pro-AD. Comparison of prodromal patients to healthy elderly controls showed the involvement of the same regions. In DLB-d (p<0.05, FDR corrected) cortical thinning was found predominantly in the right temporo-parietal junction, and insula, cingulate, orbitofrontal and lateral occipital cortices. In AD-d(p<0.05, FDR corrected), the most significant areas affected included the entorhinal cortices, parahippocampal gyri and parietal lobes. The comparison of AD-d and DLB-d demonstrated more CTh in AD-d in the left entorhinal cortex (p<0.05, FDR corrected). Conclusion Cortical thickness is a sensitive measure for characterising patterns of grey matter atrophy in early stages of DLB distinct from AD. Right anterior insula involvement may be a key region at the prodromal stage of DLB and needs further investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available