4.6 Article

Molecular Design and Synthesis of Novel Salicyl Glycoconjugates as Elicitors against Plant Diseases

Journal

PLOS ONE
Volume 9, Issue 9, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0108338

Keywords

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Funding

  1. National Key Project for Basic Research [2015CB150605]
  2. National Natural Science Foundation of China [21102173]
  3. State Key Laboratory for Biology of Plant Diseases and Insect Pests [SKLOF201411]
  4. Specialty and Innovation Projects of Guangdong Province University
  5. President Science Foundation of South China Agricultural University [4200-K13014]
  6. Japan Society for the Promotion of Science (JSPS) [P10100]
  7. Advanced Multi-Career Training Program for Postdoctoral Scholars from JST
  8. VBL project from Chiba University

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A new series of salicyl glycoconjugates containing hydrazide and hydrazone moieties were designed and synthesized. The bioassay indicated that the novel compounds had no in vitro fungicidal activity but showed significant in vivo antifungal activity against the tested fungal pathogens. Some compounds even had superior activity than the commercial fungicides in greenhouse trial. The results of RT-PCR analysis showed that the designed salicyl glycoconjugates could induce the expression of LOX1 and Cs-AOS2, which are the specific marker genes of jasmonate signaling pathway, to trigger the plant defense resistance.

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