Journal
PLOS ONE
Volume 9, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0100760
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Funding
- LabEx DISTALZ (an excellent laboratory-Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer's disease)
- FUI MEDIALZ
- CPER DN2M (VICTAUR)
- Inserm
- CNRS
- University of Lille 2
- Lille Metropole Communaute Urbaine (LMCU)
- Region Nord/Pas-de-Calais
- FEDER
- 'Fondation Plan Alzheimer' (PRIMATAU)
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Tau is a microtubule-associated protein that aggregates in neurodegenerative disorders known as tauopathies. Recently, studies have suggested that Tau may be secreted and play a role in neural network signalling. However, once deregulated, secreted Tau may also participate in the spreading of Tau pathology in hierarchical pathways of neurodegeneration. The mechanisms underlying neuron-to-neuron Tau transfer are still unknown; given the known role of extra-cellular vesicles in cell-to-cell communication, we wondered whether these vesicles could carry secreted Tau. We found, among vesicles, that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.
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