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Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
Jinling Hou et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes
Zhao Zhong Chong et al.
CURRENT NEUROVASCULAR RESEARCH (2011)
FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
Shiqin Xiong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus
Kenneth Maiese et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2011)
Insulin-Like Growth Factor-I-Forkhead Box O Transcription Factor 3a Counteracts High Glucose/Tumor Necrosis Factor-α-Mediated Neuronal Damage: Implications for Human Immunodeficiency Virus Encephalitis
Anna Wilk et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
Francesca L'Episcopo et al.
MOLECULAR NEURODEGENERATION (2011)
Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
F. L'Episcopo et al.
NEUROBIOLOGY OF DISEASE (2011)
Forkhead transcription factors in ovarian function
Nina Henriette Uhlenhaut et al.
REPRODUCTION (2011)
Discovery of Nonsteroidal Anti-Inflammatory Drug and Anticancer Drug Enhancing Reprogramming and Induced Pluripotent Stem Cell Generation
Chao-Shun Yang et al.
STEM CELLS (2011)
SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
Hee-Don Chae et al.
STEM CELLS AND DEVELOPMENT (2011)
Phosphatidylserine targeting for diagnosis and treatment of human diseases
Kristof Schutters et al.
APOPTOSIS (2010)
Wnt1, FoxO3a, and NF-κB oversee microglial integrity and activation during oxidant stress
Yan Chen Shang et al.
CELLULAR SIGNALLING (2010)
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
Nirmala Hariharan et al.
CIRCULATION RESEARCH (2010)
Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
Jinling Hou et al.
CURRENT NEUROVASCULAR RESEARCH (2010)
Oxidative stress: Biomarkers and novel therapeutic pathways
Kenneth Maiese et al.
EXPERIMENTAL GERONTOLOGY (2010)
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
Monica Dentice et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Mechanical Activation of β-Catenin Regulates Phenotype in Adult Murine Marrow-Derived Mesenchymal Stem Cells
Natasha Case et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2010)
FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling
Jinling Hou et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
Jonathan H. Fox et al.
MOLECULAR NEURODEGENERATION (2010)
Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways
Zhao Zhong Chong et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
FoxO proteins: cunning concepts and considerations for the cardiovascular system
Kenneth Maiese et al.
CLINICAL SCIENCE (2009)
The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3
Yan Chen Shang et al.
CURRENT NEUROVASCULAR RESEARCH (2009)
FoxO3a Governs Early Microglial Proliferation and Employs Mitochondrial Depolarization with Caspase 3, 8, and 9 Cleavage During Oxidant Induced Apoptosis
Yan Chen Shang et al.
CURRENT NEUROVASCULAR RESEARCH (2009)
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Kenneth Maiese et al.
MOLECULES (2009)
A fork in the path Developing therapeutic inroads with FoxO proteins
Kenneth Maiese et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2009)
Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology
Kenneth Maiese et al.
THESCIENTIFICWORLDJOURNAL (2009)
FoxO tumor suppressors and BCR-ABL-induced leukemia: A matter of evasion of apoptosis
Zainab Jagani et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2008)
Clever cancer strategies with FoxO transcription factors
Kenneth Maiese et al.
CELL CYCLE (2008)
Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily
Jae J. Song et al.
CELLULAR SIGNALLING (2008)
Raves and risks for erythropoietin
Kenneth Maiese et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2008)
Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and forkhead signaling?
Kenneth Maiese et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2008)
Interaction of FOXO with β-catenin inhibits β-Catenin/T cell factor activity
Diana Hoogeboom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis
Tomohiro Nakamura et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)
The Wnt signaling pathway: Aging gracefully as a protectionist?
Kenneth Maiese et al.
PHARMACOLOGY & THERAPEUTICS (2008)
Exercise training promotes SIRT1 activity in aged rats
Nicola Ferrara et al.
REJUVENATION RESEARCH (2008)
Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies
Kenneth Maiese et al.
PROGRESS IN NEUROBIOLOGY (2008)
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
Kenneth Maiese et al.
TRENDS IN MOLECULAR MEDICINE (2008)
A winged-helix protein from suffiblobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus
Eric T. Larson et al.
VIROLOGY (2007)
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification
Kuang-Lei Tsai et al.
NUCLEIC ACIDS RESEARCH (2007)
The emerging roles of forkhead box (Fox) proteins in cancer
Stephen S. Myatt et al.
NATURE REVIEWS CANCER (2007)
Sly as a FOXO: New paths with forkhead signaling in the brain
Kenneth Maiese et al.
CURRENT NEUROVASCULAR RESEARCH (2007)
Trastuzumab-resistant HER2-Driven breast cancer cells are sensitive to epigallocatechin-3 gallate
Sean F. Eddy et al.
CANCER RESEARCH (2007)
Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to Forkhead box O-mediated transcription
Maria Almeida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The genetics of very early onset Alzheimer disease
Christopher M. Filley et al.
COGNITIVE AND BEHAVIORAL NEUROLOGY (2007)
Dynamic FoxO transcription factors
Haojie Huang et al.
JOURNAL OF CELL SCIENCE (2007)
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Kana Miyamoto et al.
CELL STEM CELL (2007)
Cellular demise and inflammatory microglial activation during β-amyloid toxicity are governed by Wnt1 and canonical signaling pathways
Zhao Zhong Chong et al.
CELLULAR SIGNALLING (2007)
Sirt1 regulates aging and resistance to oxidative stress in the heart
Ralph R. Alcendor et al.
CIRCULATION RESEARCH (2007)
Differential regulation of Foxo3a target genes in erythropoiesis
Walbert J. Bakker et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
Z. Z. Chong et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Zuzana Tothova et al.
CELL (2007)
Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a
Lian Liu et al.
DEVELOPMENT (2007)
Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
P. Obexer et al.
CELL DEATH AND DIFFERENTIATION (2007)
Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
Muyao Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization
Takeshi Kajihara et al.
MOLECULAR ENDOCRINOLOGY (2006)
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
Maria K. Lehtinen et al.
CELL (2006)
Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation
CK Won et al.
NEUROSCIENCE LETTERS (2006)
Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and β-catenin during oxidative stress
Zhao Zhong Chong et al.
CURRENT NEUROVASCULAR RESEARCH (2006)
GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway
M Anitha et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
MFM Hoekman et al.
GENE EXPRESSION PATTERNS (2006)
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
LP Van der Heide et al.
BIOCHEMICAL JOURNAL (2005)
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
H Matsuzaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
J Sunayama et al.
JOURNAL OF CELL BIOLOGY (2005)
Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease
ZZ Chong et al.
BRAIN RESEARCH REVIEWS (2005)
Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/forkhead pathway for GDNF-stimulated survival
S Srinivasan et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
BA He et al.
ONCOGENE (2005)
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
ZZ Chong et al.
PROGRESS IN NEUROBIOLOGY (2005)
New avenues of exploration for erythropoietin
K Maiese et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
MCT Hu et al.
CELL (2004)
Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin
E Arimoto-Ishida et al.
ENDOCRINOLOGY (2004)
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
T Hosaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
H Miyauchi et al.
EMBO JOURNAL (2004)
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
Y Kamei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
WW Zhu et al.
MOLECULAR BRAIN RESEARCH (2004)
The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
ZZ Chong et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)
AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9
ZZ Chonga et al.
EXPERIMENTAL CELL RESEARCH (2004)
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation
LP van der Heide et al.
BIOCHEMICAL JOURNAL (2004)
Erythropoietin in the brain: can the promise to protect be fulfilled?
K Maiese et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
H Matsuzaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
C Charvet et al.
ONCOGENE (2003)
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
DH Castrillon et al.
SCIENCE (2003)
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
DR Plas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
ZZ Chong et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8
ZZ Chong et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Expression of the serum- and glueocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells
MLL Leong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
ZZ Chong et al.
CIRCULATION (2002)
FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
WH Zheng et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
WH Biggs et al.
MAMMALIAN GENOME (2001)
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