Journal
VIRUSES-BASEL
Volume 7, Issue 4, Pages 1613-1626Publisher
MDPI
DOI: 10.3390/v7041613
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Funding
- National Programs for High Technology Research and Development of China [2011AA10A211-5]
- National Natural Science Foundation of China (NSFC) [31170144]
- Key Project of Chinese Ministry of Education [NCET-09-0402]
- Fundamental Research Funds for the Central Universities [2010PY001, 2011PY050]
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Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection.
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