Journal
VIRUSES-BASEL
Volume 7, Issue 7, Pages 4047-4074Publisher
MDPI
DOI: 10.3390/v7072805
Keywords
human; HTLV-I infections; T-lymphotrophic virus 1; leukemia-lymphoma; adult T-cell; microRNAs; virus replication; cell line; cell transformation; gene expression regulation
Categories
Funding
- [106258]
Ask authors/readers for more resources
Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available