Journal
VIRUSES-BASEL
Volume 7, Issue 12, Pages 6291-6312Publisher
MDPI
DOI: 10.3390/v7122938
Keywords
oncolytic virus; immunotherapy; reovirus; vaccinia; HSV; clinical trials
Categories
Funding
- Yorkshire Cancer Research
- Cancer Research UK
- Cancer Research UK [13244] Funding Source: researchfish
- National Institute for Health Research [ACF-2015-02-003] Funding Source: researchfish
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The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold.
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