Journal
PLOS ONE
Volume 8, Issue 11, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0078700
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Funding
- National Natural Science Foundation of China [81202812, 81303102, 81303103]
- Shanghai Municipal Education Commission [2011JW57, 12YZ058]
- Shanghai Municipal Health Bureau [ZYSNXD-CC-YJXYY-JS20, 2011ZJ030, 20114Y001, 20114037]
- Shanghai Key Laboratory of Traditional Chinese Clinical Medicine [C10dz2220200]
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Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA and over-expression constructs in CRC derived cell lines, LoVo and HCT116, we demonstrated that the anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/beta-catenin signaling, thus the expression of its target genes such as c-Myc, MMP-7, as well as the expression of MALAT1. In detail, resveratrol down-regulates MALAT1, resulting in decreased nuclear localization of beta-catenin thus attenuated Wnt/beta-catenin signaling, which leads to the inhibition of CRC invasion and metastasis. This finding of ours surely provides important pre-clinical evidence supporting future use of resveratrol in prevention and treatment of CRC.
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