Journal
PLOS ONE
Volume 8, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0071345
Keywords
-
Categories
Funding
- UK Medical Research Council
- United States National Institutes of Health [NHLBI 33014]
- Du Pont Pharma, Wilmington, USA
- British Heart Foundation [RG/04/003, RG/07/008/23674, RG/97006]
- Medical Research Council [G0902037, G0500877]
- Stroke Association
- National Institute on Aging [5RO1AG13196]
- Agency for Health Care Policy Research [HS06516]
- John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health
- National Institute on Ageing (NIA)
- UK Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02, 057762]
- European Commission Framework Programme 6 [018996]
- French Ministry of Research
- Department of Health Policy Research Programme (England)
- Chief Scientist Office of Scotland [K/OPR/2/2/D320]
- Chest Heart and Stroke Scotland [Res03/A75]
- Bayer plc
- Chief Scientist Office of Scottish [CZQ/1/38, CZB/4/672]
- Pfizer plc
- Diabetes UK [10/0003985]
- MRC project grant
- National Heart Lung and Blood Institute [5RO1 HL036310]
- [AG1764406S1]
- ESRC [ES/J023299/1] Funding Source: UKRI
- MRC [MC_UU_12013/5, MC_U123092720, G0600237, MC_UU_12015/1, G0000934, MC_U123092721, G0902037, G0802432, MC_UU_12015/2, G1000718, MR/K013351/1, G9521010, G0500877, G0801414, MC_U106179472] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674, RG/08/008/25291, RG/13/2/30098, RG/10/12/28456, PG/13/66/30442, RG/08/013/25942] Funding Source: researchfish
- Chief Scientist Office [CZB/4/672] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1] Funding Source: researchfish
- Medical Research Council [G0802432, MR/K013351/1, G9521010, 1170444, G0801414, G0000934, G0500877, G0600237, MC_U123092721, G1000718, MC_U106179472, MC_UU_12013/5, MC_UU_12015/1, MC_UU_12015/2, G0902037, MC_U123092720, MR/K006584/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10113] Funding Source: researchfish
Ask authors/readers for more resources
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
