Journal
PLOS ONE
Volume 8, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0072767
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Funding
- Portuguese Foundation for Science and Technology (FCT) [PTDC/CVT/105022/2008]
- FCT [SFRH/BD/64416/2009, SFRH/BPD/47079/2008]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/64416/2009, SFRH/BPD/47079/2008, PTDC/CVT/105022/2008] Funding Source: FCT
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The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and time-window expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in prepubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.
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