Journal
PLOS ONE
Volume 8, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0066782
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Funding
- National Natural Science Foundation of China [30872476, 81072012, 81172324, 91229106, 30900670, 81272749]
- Science and Technology Commission of Shanghai Municipality [10jc1411100, 09DZ1950100, 09DZ2260200, 11jc1407602, 101409042000]
- Shanghai Key Discipline [S30204]
- Key Projects in the National Science & Technology Pillar Program of China [2008BA152B03, 2011BA203191]
- China Postdoctoral Science Foundation [2011M500796]
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MicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restoring miR-338-3p expression in SGC-7901 gastric cancer cells inhibited proliferation, migration, invasion and tumorigenicity in vitro and in vivo, at least partly through inducing apoptosis. Furthermore, we demonstrate the oncogene SSX2IP is a target of miR-338-3p. We propose that miR-338-3p functions as a tumor suppressor in gastric cancer, and the methylation status of its CpG island could serve as a potential diagnostic marker for gastric cancer.
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