Journal
PLOS ONE
Volume 8, Issue 1, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0054140
Keywords
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Categories
Funding
- Federal Ministry of Education and Research (BMBF)
- Boehringer Ingelheim Foundation
- Integrated Research and Treatment Center IFB Adiposity Diseases [K7-38, K7-39, K7-37, K403]
- Deutsche Forschungsgemeinschaft (DFG)
- Clinical Research Group Atherobesity [KFO 152, BL 833/1-1, Stu192/6-1, KO 3512/1-1, KO 3880/1-2]
- German Diabetes Association
- DDS Foundation
- DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland)
- LIFE - Leipzig Research Center for Civilization Diseases, Universitat Leipzig
- European Union
- European Regional Development Fund (ERDF)
- Free State of Saxony
- Federal Ministry of Education and Research (BMBF), Germany [FKZ: 01EO1001]
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Objective: The adipokine vaspin (visceral adipose tissue derived serine protease inhibitor, serpinA12) follows a meal-related diurnal variation in humans and intracerebroventricular vaspin administration leads to acutely reduced food intake in db/db mice. We therefore hypothesized that vaspin may play a role in human eating behaviour. Materials and Methods: We measured serum vaspin concentrations in 548 subjects from a self-contained population of Sorbs (Germany) who underwent detailed metabolic testing including eating behaviour assessments using the three-factor eating questionnaire. In addition, genetic variation within vaspin was assessed by genotyping 28 single nucleotide polymorphisms (SNPs) in all study subjects. Results: Serum vaspin concentrations correlated positively with restraint, disinhibition and hunger (all P<0.05), although the correlations did not withstand further adjustments for age, gender and BMI (all P>0.05). Independent of observed correlations, genetic variants in vaspin were associated with serum vaspin levels but showed no significant association with any of the eating behaviour phenotypes after accounting for multiple testing (P >= 0.05 after adjusting for age, gender and BMI). Conclusion: Our data suggest that serum vaspin concentrations might modulate human eating behaviour, which does not seem to be affected by common genetic variation in vaspin.
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