Journal
PLOS ONE
Volume 8, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0056929
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Funding
- National High Technology Research and Development Program of China [2012AA02A206]
- National Natural Science Foundation of China [91229122, 81071644, 81101509, 81171934, 81172189, 81171930, 81272298, 81272254, 30971147]
- 111 Project [111-2-12]
- Hunan Province Natural Sciences Foundation of China [10JJ7003]
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Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.
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