Journal
PLOS ONE
Volume 7, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0050141
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Funding
- Ludwig Center for Metastasis Research Grant
- Center for Radiation Therapy
- Chicago Tumor Institute
- Ludwig Foundation for Cancer Research
- Foglia Foundation
- Lung Cancer Research Foundation
- Cancer Research Foundation
- Institutes of Health (NIH) [K22 LM008308-04, 5UL1RR024999-04]
- University of Chicago Comprehensive Cancer Center [5P30CA014599-35]
- University of Illinois Cancer Center
- University of Illinois Center for Clinical and Translational Science [UL1RR029879]
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Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy. Methods: We analyzed microRNA expression patterns from lung metastasis samples of patients with <= 5 initial metastases resected with curative intent. Results: Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset. Conclusion: Oligo-and poly-metastasis are distinct entities at the clinical and molecular level.
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