Journal
PLOS ONE
Volume 7, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0047122
Keywords
-
Categories
Funding
- National Research Foundation of Korea (NRF)
- Korean government (Ministry of Education, Science and Technology
- MEST) [20110028772, 2011k000273, 20110006229]
- KRIBB (Korea Research Institute Bioscience and Biotechnology) Research Initiative Program of Korea
Ask authors/readers for more resources
NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD(+)/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding beta-lapachone (beta L), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. beta L-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and decreased in the muscles of control diet group but those defects were less severe in beta L-fed aged mice. Furthermore, for a subset of genes associated with energy metabolism, mice fed the beta L-diet showed similar changes in gene expression to the CR group (fed 70% of the control diet). These results support the potentiation of NQO1 activity by a beta L diet and could be an option for preventing age-related decline of muscle and brain functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available