Journal
PLOS ONE
Volume 7, Issue 7, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0037659
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Funding
- Key Technologies Research and Development Program of Shandong Province [2006GG2202020, 2010G0020262]
- Natural Science Foundation of Shandong Province [Y2005C11, ZR2009CM022, ZR2009CM025, BS2009YY026]
- National Natural Science Foundation of China [30871038, 30971215, 81070192, 81070141, 81100605]
- National Basic Research Program of China (973 Program) [2009CB521904]
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Aims: The risk stratification of patients for heart failure (HF) remains a challenge, as well as the anticipation of the response to beta-blocker therapy. Since the pivotal role of beta 1 adrenergic receptor (beta 1-AR) in HF, many publications have studied the associations between the beta 1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. Thus, we performed a meta-analysis of studies to evaluate the impact of beta 1-AR polymorphisms on susceptibility to HF, the response to beta-blocker therapy and the prognosis of HF. Methods and Results: Electronic databases were systematically searched before August 2011. We extracted data sets and performed meta-analysis with standardized methods. A total of 27 studies met our inclusion criteria. It was found that in East Asians, the Gly389 allele and Gly389 homozygotes significantly increased the HF risk, while the Gly389 allele and Gly389 homozygotes trended to decrease the risk of HF in whites. With the similar reduction of heart rate, overall, the Arg389 homozygotes showed a better response to beta-blocker therapy. Furthermore, the Arg389 homozygotes were significantly associated with better LVEF improvement in East Asians and a mixed population. And in white people, the Arg389 homozygotes made a greater LVESd/v improvement and trended to be associated with better LVEDd/v improvement. However, the prognosis of Arg389 homozygotes HF patients was similar to those with Gly389 carriers. The Ser49Gly polymorphism did not impact the risk or prognosis of HF. Conclusion: Based on our meta-analysis, the Gly389 allele and Gly389 homozygotes were risk factors in East Asians while trending to protect whites against HF. Furthermore, Arg389 homozygote is significantly associated with a favorable response to beta-blocker treatment in HF patients. However, neither of the two polymorphisms is an independent predictor of the prognosis of HF.
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