Related references
Note: Only part of the references are listed.Many stimuli pull the necrotic trigger, an overview
N. Vanlangenakker et al.
CELL DEATH AND DIFFERENTIATION (2012)
Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
Ravi K. Amaravadi et al.
CLINICAL CANCER RESEARCH (2011)
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
Robin Mathew et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2011)
Pancreatic cancers require autophagy for tumor growth
Shenghong Yang et al.
GENES & DEVELOPMENT (2011)
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo et al.
GENES & DEVELOPMENT (2011)
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
Rebecca Lock et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
William J. Kaiser et al.
NATURE (2011)
Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis
Andrew Oberst et al.
NATURE (2011)
Functional complementation between FADD and RIP1 in embryos and lymphocytes
Haibing Zhang et al.
NATURE (2011)
Mechanisms of mitophagy
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis
B. J. Altman et al.
ONCOGENE (2011)
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
Andrey Parkhitko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
Ker Yu et al.
CANCER RESEARCH (2010)
Virus Inhibition of RIP3-Dependent Necrosis
Jason W. Upton et al.
CELL HOST & MICROBE (2010)
mTOR and cancer: many loops in one pathway
Alejo Efeyan et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1-and RIP3-mediated necrosis
Christiana W. Davis et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Alternative cell death mechanisms in development and beyond
Junying Yuan et al.
GENES & DEVELOPMENT (2010)
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
Alexandria Lau et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Autophagy and Metabolism
Joshua D. Rabinowitz et al.
SCIENCE (2010)
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
YoungSik Cho et al.
CELL (2009)
Autophagy Suppresses Tumorigenesis through Elimination of p62
Robin Mathew et al.
CELL (2009)
The Double-Edged Sword of Autophagy Modulation in Cancer
Eileen White et al.
CLINICAL CANCER RESEARCH (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
Cristian Bellodi et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy
Wen-Xing Ding et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma - A novel molecule that induces autophagic cell death
Sandra Turcotte et al.
AUTOPHAGY (2008)
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Daniel J. Klionsky et al.
AUTOPHAGY (2008)
Tumor suppression by autophagy through the management of metabolic stress
Shengkan Jin et al.
AUTOPHAGY (2008)
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
Sandra Turcotte et al.
CANCER CELL (2008)
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
Christin Tse et al.
CANCER RESEARCH (2008)
Necroptosis: A Specialized Pathway of Programmed Necrosis
Lorenzo Galluzzi et al.
CELL (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
Victor Y. Yazbeck et al.
EXPERIMENTAL HEMATOLOGY (2008)
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
Michael Degtyarev et al.
JOURNAL OF CELL BIOLOGY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
Taichi Hara et al.
JOURNAL OF CELL BIOLOGY (2008)
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
Kirsteen H. Maclean et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Efficacy of everolimus in advanced renal cell carcinoma:: a double-blind, randomised, placebo-controlled phase III trial
Robert J. Motzer et al.
LANCET (2008)
Identification of RIP1 kinase as a specific cellular target of necrostatins
Alexei Degterev et al.
NATURE CHEMICAL BIOLOGY (2008)
Acute Myeloid Leukemia-Targeted Toxin Activates Both Apoptotic and Necroptotic Death Mechanisms
Henrick Horita et al.
PLOS ONE (2008)
Dual roles of Nrf2 in cancer
Alexandria Lau et al.
PHARMACOLOGICAL RESEARCH (2008)
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
Tatsuhiro Shibata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Autophagy is essential for preimplantation development of mouse embryos
Satoshi Tsukamoto et al.
SCIENCE (2008)
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
Masaaki Komatsu et al.
CELL (2007)
Targeting the weak point of cancer by induction of necroptosis
Xun Hu et al.
AUTOPHAGY (2007)
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
Zheng Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
Vassiliki Karantza-Wadsworth et al.
GENES & DEVELOPMENT (2007)
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
Jennifer S. Carew et al.
BLOOD (2007)
Autophagy suppresses tumor progression by limiting chromosomal instability
Robin Mathew et al.
GENES & DEVELOPMENT (2007)
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Ravi K. Amaravadi et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
Min Wu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Dynamics of the cellular metabolome during human cytomegalovirus infection
Joshua Munger et al.
PLOS PATHOGENS (2006)
Genome-scale loss-of-function screening with a lentiviral RNAi library
David E. Root et al.
NATURE METHODS (2006)
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Kurt Degenhardt et al.
CANCER CELL (2006)
Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
Maria Salazar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibition of macroautophagy triggers apoptosis
P Boya et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
DA Nelson et al.
GENES & DEVELOPMENT (2004)
The role of autophagy during the early neonatal starvation period
A Kuma et al.
NATURE (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Share Paper
