Journal
PLOS ONE
Volume 7, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0043132
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Funding
- Consejo Superior de Deportes [001/UPR10/12]
- Spanish Ministry of Science and Innovation [RYC-2010-05957]
- Fondo de Investigaciones Sanitarias [PS09/00194]
- Polish Ministry of Science and Higher Education [404166334]
- Ministry of Sport, Tourism and Youth Policy of the Russian Federation
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The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case: control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [ 633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34-0.48; P = 0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95% CI: 1.07-3.31; P = 0.028). In endurance athletes, the OR of a world-class competitor having the XX genotype versus the RR+RX genotype was 3.74 (95% CI: 1.08-12.94; P = 0.038) compared with those of a lower (national) competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance.
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