Journal
PLOS ONE
Volume 7, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0044763
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Categories
Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [N01 AI50023]
- British Columbia Children's Hospital Foundation
- Martha Piper Fund
- Peter Wall Institute for Advanced Studies
- Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund
- Candian Institute of Health Research (CIHR) Training Grant in Canadian Child Health Clinician Scientist Program
- SickKids Foundation
- Child & Family Research Institute (BC)
- Women & Children's Health Research Institute (Alberta)
- Manitoba Institute of Child Health
- Michael Smith Foundation for Health Research [ST-SGS-02657(09-1)CLIN]
- CIHR Canada-HOPE Scholarship
- National Health Laboratory Service Research Trust [TY94171]
- National Health Laboratory Service, K Fund [KNC97, KNC103]
- Poliomyelitis Research Foundation [10/02, 10/31, 11/37]
- Harry Crossley Foundation [5415, 5762]
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The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies.
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