Journal
PLOS ONE
Volume 7, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0038559
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Funding
- Ministry of Health of Portugal
- Ministery of Science, Technology and Superior Education-FCT (Fundacao para a Ciencia e Tecnologia) [SFRH/BPD/72932/2010]
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Purpose: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. Methods: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. Results: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. Conclusions: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.
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