4.6 Article

Identification of Cancer Cell-Line Origins Using Fluorescence Image-Based Phenomic Screening

Journal

PLOS ONE
Volume 7, Issue 2, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0032096

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Funding

  1. Agency for Science, Technology and Research (A*STAR)
  2. Singapore Biomedical Research Council
  3. A*STAR SSCC [SSCC10/024]
  4. Ministry of Education, Science and Technology [2010K001410]
  5. T. J. Park Science Fellowship

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Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

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