Journal
PLOS ONE
Volume 7, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0033060
Keywords
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Categories
Funding
- Wallace H. Coulter Translational Partners Grant Program Award
- Northeastern Ohio Animal Imaging Resource Center, an National Institutes of Health (NIH) of the Case Center for Imaging Research [R24CA110943]
- National Cancer Institute (NCI) [CA101954, CA116257]
- Ivy Brain Tumor Foundation
- Cancer Genome Atlas (TCGA)
- NIH [R01 EB005011-04]
- NIH Roadmap National Technology center for Networks and Pathways [U54020843-05]
- [ROI CA109620-01A1]
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Several investigators have shown the utility of systemically delivered optical imaging probes to image tumors in small animal models of cancer. Here we demonstrate an innovative method for imaging tumors and tumor margins during surgery. Specifically, we show that optical imaging probes topically applied to tumors and surrounding normal tissue rapidly differentiate between tissues. In contrast to systemic delivery of optical imaging probes which label tumors uniformly over time, topical probe application results in rapid and robust probe activation that is detectable as early as 5 minutes following application. Importantly, labeling is primarily associated with peri-tumor spaces. This methodology provides a means for rapid visualization of tumor and potentially infiltrating tumor cells and has potential applications for directed surgical excision of tumor tissues. Furthermore, this technology could find use in surgical resections for any tumors having differential regulation of cysteine cathepsin activity.
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