Related references
Note: Only part of the references are listed.Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt
Shotaro Nakajima et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease
Jeremie Vitte et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
Xianting Li et al.
JOURNAL OF NEUROSCIENCE (2010)
The Biology and Pathology of the Familial Parkinson's Disease Protein LRRK2
William Dauer et al.
MOVEMENT DISORDERS (2010)
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
Stephan Gehrke et al.
NATURE (2010)
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
Chen Yao et al.
NEUROBIOLOGY OF DISEASE (2010)
LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins
C. H. Hsu et al.
NEURODEGENERATIVE DISEASES (2010)
Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
Pengxiu Cao et al.
PLOS ONE (2010)
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
Azad Kumar et al.
PLOS ONE (2010)
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
Elisa Greggio et al.
ASN NEURO (2009)
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
Elisa Greggio et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
LRRK2 Gene Variation and Its Contribution to Parkinson Disease
Coro Paisan-Ruiz
HUMAN MUTATION (2009)
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
Christian Johannes Gloeckner et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
Loukia Parisiadou et al.
JOURNAL OF NEUROSCIENCE (2009)
Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
Chee-Hoe Ng et al.
JOURNAL OF NEUROSCIENCE (2009)
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
Shamol Saha et al.
JOURNAL OF NEUROSCIENCE (2009)
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
NATURE NEUROSCIENCE (2009)
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
Luke S. Tain et al.
NATURE NEUROSCIENCE (2009)
Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Xian Lin et al.
NEURON (2009)
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The complexity of mitogen-activated protein kinases (MAPKs) made simple
M. Krishna et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
Danling Wang et al.
MOLECULAR NEURODEGENERATION (2008)
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
Anthony K. F. Liou et al.
NEUROBIOLOGY OF DISEASE (2008)
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo
Larry J. Bischof et al.
PLOS PATHOGENS (2008)
6-hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA
Maria Gomez-Lazaro et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors
Rachel T. Wragg et al.
JOURNAL OF NEUROSCIENCE (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
Sung Bae Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease
Linda R. White et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins
Aisa Sakaguchi-Nakashima et al.
CURRENT BIOLOGY (2007)
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
Magali Periquet et al.
JOURNAL OF NEUROSCIENCE (2007)
Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells
Sergey V. Krysov et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Antony A. Cooper et al.
SCIENCE (2006)
Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells
Akiko Yamamuro et al.
NEUROCHEMICAL RESEARCH (2006)
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
J Simón-Sánchez et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
AC Ranganathan et al.
CANCER RESEARCH (2006)
Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans
T Kuwahara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain
H Melrose et al.
NEUROSCIENCE (2006)
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
WW Smith et al.
HUMAN MOLECULAR GENETICS (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans
T Yabe et al.
DEVELOPMENT (2005)
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
L Chen et al.
NATURE NEUROSCIENCE (2005)
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism:: Evidence of a common founder across European populations
J Kachergus et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2005)
p38α, but not p38β, inhibits the phosphorylation and presence of c-FLIPs in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling
L Tourian et al.
JOURNAL OF CELL SCIENCE (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8-and-9-mediated apoptotic pathways in dopaminergic neurons
WS Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Proteomic analysis reveals upregulation of calreticulin in murine dopaminergic neuronal cells after treatment with 6-hydroxydopamine
YM Lee et al.
NEUROSCIENCE LETTERS (2003)
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
WA Holtz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
DH Kim et al.
SCIENCE (2002)
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
K Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
R Nass et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease
M Lundblad et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
The C-elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion
PJ Brockie et al.
NEURON (2001)
Inhibition of p38 kinase reveals a TNF-α-mediated, caspase-dependent, apoptotic death pathway in a human myelomonocyte cell line
J Varghese et al.
JOURNAL OF IMMUNOLOGY (2001)
Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
ANT Kong et al.
ARCHIVES OF PHARMACAL RESEARCH (2000)