4.6 Article

Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

The Biology and Pathology of the Familial Parkinson's Disease Protein LRRK2

William Dauer et al.

MOVEMENT DISORDERS (2010)

Article Multidisciplinary Sciences

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Stephan Gehrke et al.

NATURE (2010)

Article Clinical Neurology

LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

C. H. Hsu et al.

NEURODEGENERATIVE DISEASES (2010)

Article Multidisciplinary Sciences

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

Youren Tong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

Elisa Greggio et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Genetics & Heredity

LRRK2 Gene Variation and Its Contribution to Parkinson Disease

Coro Paisan-Ruiz

HUMAN MUTATION (2009)

Article Biochemistry & Molecular Biology

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

Christian Johannes Gloeckner et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Neurosciences

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

Shamol Saha et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Neurosciences

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Luke S. Tain et al.

NATURE NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Han Seok Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

Youren Tong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

The complexity of mitogen-activated protein kinases (MAPKs) made simple

M. Krishna et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemistry & Molecular Biology

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

Yuzuru Imai et al.

EMBO JOURNAL (2008)

Article Neurosciences

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

Anthony K. F. Liou et al.

NEUROBIOLOGY OF DISEASE (2008)

Article Multidisciplinary Sciences

A Drosophila model for LRRK2-linked parkinsonism

Zhaohui Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease

Tiago Fleming Outeiro et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Mahaboobi Jaleel et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila

Sung Bae Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Neurosciences

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease

Linda R. White et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

Article Biochemistry & Molecular Biology

LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins

Aisa Sakaguchi-Nakashima et al.

CURRENT BIOLOGY (2007)

Article Neurosciences

Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo

Magali Periquet et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Neurosciences

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith et al.

NATURE NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Antony A. Cooper et al.

SCIENCE (2006)

Article Neurosciences

LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain

J Simón-Sánchez et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

T Kuwahara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Neurosciences

Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain

H Melrose et al.

NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

AB West et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

WA Holtz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity

DH Kim et al.

SCIENCE (2002)

Article Multidisciplinary Sciences

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

R Nass et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)