Journal
PLOS ONE
Volume 6, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0024987
Keywords
-
Categories
Funding
- Ovarian Cancer Research Fund
- National Breast Cancer Foundation
- National Health and Medical Research Council of Australia
- Cancer Council of Queensland
- Cancer Council of New South Wales
- Cancer Council of Western Australia
- Cancer Council of South Australia
- Cancer Council of Victoria
- National Health and Medical Research Council (NHMRC) of Australia [145684, 288704]
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- National Health and Medical Research Council of Australia [199600]
- Cancer Council Tasmania
- Cancer Foundation of Western Australia
- Cancer Institute NSW
- Nationaal Kankerplan
- U.S. National Institutes of Health [R01 CA58598, N01-CN-55424, N01-PC-67001]
- Cancer Research-UK [C1287/A10118, C490/A11021, C8197/A10123]
- Deutsche Krebshilfe e.V. [70-2892-BR I]
- Hamburg Cancer Society
- German Cancer Research Center (DKFZ)
- Federal Ministry of Education and Research (BMBF) Germany [01KH0402]
- Deutsche Krebshilfe e. V. [70492]
- state of Baden-Wurttemberg through the Medical Faculty of the University of Ulm [P.685]
- British Columbia Workers Compensation Board
- Canadian Institutes for Health
- Cancer Institute of New Jersey
- Cancer Research UK
- Eve Appeal
- OAK Foundation
- Department of Health's NIHR Biomedical Research Centre
- Breast Cancer Research Trust, UK
- NHMRC [1012023]
- [R01 CA122443]
- [P50 CA136939]
- [NIH-K07]
- [CA095666]
- [R01CA83918]
- MRC [G0801875] Funding Source: UKRI
- Cancer Research UK [10118, 11022] Funding Source: researchfish
- Medical Research Council [G0801875] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10124] Funding Source: researchfish
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Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.
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