Related references
Note: Only part of the references are listed.A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
Julien Dusonchet et al.
JOURNAL OF NEUROSCIENCE (2011)
Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
Xianting Li et al.
JOURNAL OF NEUROSCIENCE (2010)
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
Byoung Dae Lee et al.
NATURE MEDICINE (2010)
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
H. L. Melrose et al.
NEUROBIOLOGY OF DISEASE (2010)
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
Yulan Xiong et al.
PLOS GENETICS (2010)
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
Elisa Greggio et al.
ASN NEURO (2009)
Mendelian forms of Parkinson's disease
Thomas Gasser
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
Javier Alegre-Abarrategui et al.
HUMAN MOLECULAR GENETICS (2009)
Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
Loukia Parisiadou et al.
JOURNAL OF NEUROSCIENCE (2009)
Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
Chee-Hoe Ng et al.
JOURNAL OF NEUROSCIENCE (2009)
Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
Eva Andres-Mateos et al.
JOURNAL OF NEUROSCIENCE (2009)
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
Shamol Saha et al.
JOURNAL OF NEUROSCIENCE (2009)
Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
Joao Paulo L. Daher et al.
MOLECULAR NEURODEGENERATION (2009)
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
NATURE NEUROSCIENCE (2009)
Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Xian Lin et al.
NEURON (2009)
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
Youren Tong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease
Darren J. Moore et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2008)
Parkin mediates the degradation-independent ubiquitination of Hsp70
Darren J. Moore et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
Edward D. Plowey et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease
Ying Liu et al.
JOURNAL OF NEUROSCIENCE (2008)
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
Lizhen Wang et al.
JOURNAL OF NEUROSCIENCE (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
Danling Wang et al.
MOLECULAR NEURODEGENERATION (2008)
A Calcium-Dependent Switch in a CREST-BRG1 Complex Regulates Activity-Dependent Gene Expression
Zilong Qiu et al.
NEURON (2008)
Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease
M. Westerlund et al.
NEUROSCIENCE (2008)
The biology and pathobiology of LRRK2: Implications for Parkinson's disease
Darren J. Moore
PARKINSONISM & RELATED DISORDERS (2008)
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain
Shinji Higashi et al.
BRAIN RESEARCH (2007)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Patrick A. Lewis et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins
Aisa Sakaguchi-Nakashima et al.
CURRENT BIOLOGY (2007)
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
Genta Ito et al.
BIOCHEMISTRY (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
The Parkinson disease gene LRRK2:: Evolutionary and structural insights
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION (2006)
The family of sensorimotor gating disorders: Comorbidities or diagnostic overlaps?
Mark A. Geyer
NEUROTOXICITY RESEARCH (2006)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
Christian Frezza et al.
CELL (2006)
PARK8 LRRK2 parkinsonism
Kristoffer Haugarvoll et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2006)
LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
ANNALS OF NEUROLOGY (2006)
Biochemical and pathological characterization of Lrrk2
BI Giasson et al.
ANNALS OF NEUROLOGY (2006)
LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
S Lesage et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
LJ Ozelius et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Improved neuronal transgene expression from an AAV-2 vector with a hybrid CMV enhancer/PDGF-β promoter
CY Wang et al.
JOURNAL OF GENE MEDICINE (2005)
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
M Funayama et al.
ANNALS OF NEUROLOGY (2005)
CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression
BH Liu et al.
GENE THERAPY (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Dopaminergic loss and inclusion body formation in α-synuclein mice:: Implications for neurodegenerative disorders
E Masliah et al.
SCIENCE (2000)
Share Paper
