Journal
PLOS ONE
Volume 6, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0017700
Keywords
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Categories
Funding
- Academy of Finland [135252, 132700, 132894, 126775, 129255, 129907, 135072, 127437, 129306, 130326, 134791]
- Biomedicum Helsinki Foundation
- Finnish Concordia Foundation
- Finska Lakaresallskapet
- Finnish Medical Society Duodecim
- Finnish Foundation for Pediatric Research
- Finnish Pediatric Society
- Finnish Special Governmental Subsidy for Health Sciences
- Finnish National Graduate School of Clinical Investigation
- Jalmari and Rauha Ahokas Foundation
- Juho Vainio Foundation
- Novo Nordisk Foundation
- Paivikki and Sakari Sohlberg Foundation
- Pediatric Graduate School and the Clinical Graduate School in Paediatrics and Obstetrics/Gynaecology, University of Helsinki
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Vasa Nation and Wiipurilainen osakunta at Helsinki University
- Wilhelm and Else Stockmann Foundation
- Yrjo Jahnsson Foundation
- Academy of Finland (AKA) [135252, 132700, 132894, 132894, 135252, 132700] Funding Source: Academy of Finland (AKA)
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Background: Adults born preterm with very low birth weight (VLBW; < 1500g) have higher levels of cardiovascular and metabolic risk factors than their counterparts born at term. Resting energy expenditure (REE) could be one factor contributing to, or protecting from, these risks. We studied the effects of premature birth with VLBW on REE. Methodology/Principal Findings: We used indirect calorimetry to measure REE and dual x-ray absorptiometry (DXA) to measure lean body mass (LBM) in 116 VLBW and in 118 term-born control individuals (mean age: 22.5 years, SD 2.2) participating in a cohort study. Compared with controls VLBW adults had 6.3% lower REE (95% CI 3.2, 9.3) adjusted for age and sex, but 6.1% higher REE/LBM ratio (95% CI 3.4, 8.6). These differences remained similar when further adjusted for parental education, daily smoking, body fat percentage and self-reported leisure time exercise intensity, duration and frequency. Conclusions/Significance: Adults born prematurely with very low birth weight have higher resting energy expenditure per unit lean body mass than their peers born at term. This is not explained by differences in childhood socio-economic status, current fat percentage, smoking or leisure time physical activity. Presence of metabolically more active tissue could protect people with very low birth weight from obesity and subsequent risk of chronic disease.
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