Related references
Note: Only part of the references are listed.Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites
Alexander E. Davies et al.
JOURNAL OF CELL BIOLOGY (2010)
Heat Shock Protein 90: Inhibitors in Clinical Trials
Marco A. Biamonte et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
Nicholas Kwiatkowski et al.
NATURE CHEMICAL BIOLOGY (2010)
Death by chaperone HSP90, HSP70 or both?
Marissa V. Powers et al.
CELL CYCLE (2009)
Heat Shock Protein 90 as a Drug Target: Some Like It Hot
Udai Banerji
CLINICAL CANCER RESEARCH (2009)
17 AAG for HSP90 Inhibition in Cancer - From Bench to Bedside
Saad Z. Usmani et al.
CURRENT MOLECULAR MEDICINE (2009)
Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization
Torcato Martins et al.
EMBO JOURNAL (2009)
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
Arne Lindqvist et al.
JOURNAL OF CELL BIOLOGY (2009)
Molecular Dissection of the Centrosome Overduplication Pathway in S-Phase-Arrested Cells
Suzanna L. Prosser et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Polo-like kinases: conservation and divergence in their functions and regulation
Vincent Archambault et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres et al.
NATURE REVIEWS CANCER (2009)
90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G(2)/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1
Archie N. Tse et al.
MOLECULAR PHARMACOLOGY (2009)
Mps1 phosphorylates borealin to control aurora B activity and chromosome alignment
Nannette Jelluma et al.
CELL (2008)
Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells
M. K. Borysova et al.
CELL CYCLE (2008)
HSP90 - The Rosetta stone for cellular protein dynamics?
Diane C. DeZwaan et al.
CELL CYCLE (2008)
Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics
Alain C. Mita et al.
CLINICAL CANCER RESEARCH (2008)
Polo on the rise -: from mitotic entry to cytokinesis with Plk1
Mark Petronczki et al.
DEVELOPMENTAL CELL (2008)
CDK inhibitors: Cell cycle regulators and beyond
Arnaud Besson et al.
DEVELOPMENTAL CELL (2008)
Inhibition of Hsp90 Leads to Cell Cycle Arrest and Apoptosis in Human Malignant Pleural Mesothelioma
Junichi Okamoto et al.
JOURNAL OF THORACIC ONCOLOGY (2008)
A novel role for Cdk1/cyclin B in regulating B-Raf activation at mitosis
Sergiy I. Borysov et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines
Magdalena Zajac et al.
MOLECULAR CANCER THERAPEUTICS (2008)
A bitter PP1 fights the sweet polo
Vincent Archambault et al.
MOLECULAR CELL (2008)
Chaperone-dependent stabilization and degradation of p53 mutants
P. Muller et al.
ONCOGENE (2008)
Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells
D. M. Moran et al.
ONCOGENE (2008)
Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1
K. Sugimoto et al.
ONCOGENE (2008)
B-RafV600E signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells
Y. Cui et al.
ONCOGENE (2008)
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells
K. Lin et al.
ONCOGENE (2008)
Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo
Joerg Schwock et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2008)
Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G2/M arrest in glioblastoma cell lines
P. Garcia-Morales et al.
ONCOGENE (2007)
HSP90 antagonist, geldanamycin, inhibits proliferation, induces appptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo
Ewa Lesko et al.
ANTI-CANCER DRUGS (2007)
Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines
Tatiana V. Rakitina et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
Ruediger Neef et al.
NATURE CELL BIOLOGY (2007)
Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans
Renata Basto et al.
JOURNAL OF CELL SCIENCE (2007)
p53 in health and disease
Karen H. Vousden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
Campbell McInnes et al.
NATURE CHEMICAL BIOLOGY (2006)
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9
Georgios V. Georgakis et al.
BRITISH JOURNAL OF HAEMATOLOGY (2006)
Structure of an Hsp90-Cdc37-Cdk4 complex
Cara K. Vaughan et al.
MOLECULAR CELL (2006)
Raf kinase inhibitory protein regulates Aurora B kinase and the spindle checkpoint
Eva M. Eves et al.
MOLECULAR CELL (2006)
17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation
Y. Niikura et al.
ONCOGENE (2006)
Down-regulation of polo-like kinase 1 elevates drug sensitivity of breast cancer cells in vitro and in vivo
Birgit Spaenkuch et al.
CANCER RESEARCH (2006)
Check, double check the G2 barrier to cancer
Floris Foijer et al.
CELL CYCLE (2006)
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines
M Senju et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2006)
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
OM Grbovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
SD Dias et al.
CANCER RESEARCH (2005)
Cdk2: A genuine protein kinase client of Hsp90 and Cdc37
T Prince et al.
BIOCHEMISTRY (2005)
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
T Shimamura et al.
CANCER RESEARCH (2005)
Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53 -: Implications for cancer therapy
P Müller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis
MATM van Vugt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner
G de Cárcer
CANCER RESEARCH (2004)
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles
I Sumara et al.
CURRENT BIOLOGY (2004)
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress
SJH Arlander et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Regulation of survivin function by Hsp90
P Fortugno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Survivin is required for stable checkpoint activation in taxol-treated HeLa cells
A Carvalho et al.
JOURNAL OF CELL SCIENCE (2003)
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
ST Liu et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Mutations of the BRAF gene in human cancer
H Davies et al.
NATURE (2002)
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
BHP Zhou et al.
NATURE CELL BIOLOGY (2001)
Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines
S Simizu et al.
NATURE CELL BIOLOGY (2000)
Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates
BMH Lange et al.
EMBO JOURNAL (2000)