Journal
PLOS ONE
Volume 5, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0013261
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Categories
Funding
- Netherlands Organisation for Health Research and Development [2100.0090, 912-03-031]
- Netherlands Asthma Foundation [3.2.03.48]
- Royal Friesland Foods, Triodos Foundation
- Phoenix Foundation
- Raphae Foundation
- Iona Foundation
- Foundation for the Advancement of Heilpedagogie
- Netherlands Ministry of Public Health, Welfare and Sport
- Netherlands and the Netherlands Organisation for Scientific Research
- Federal Ministry for Education, Science, Research and Technology [01 EG 9705/2, 01EG9732]
- Federal Ministry of Education and Research [01GI0826, 01GI0823, 01GS0820]
- Munich Center of Health Sciences (MCHEALTH), Ludwig-Maximilians University Munich LMU
- Netherlands Organisation for Scientific Research
- Bristol-Myers-Squibb Foundation, New York, NY, USA
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Background: Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied. Methods and Principal Findings: Data of two population-based-birth-cohorts in the Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort. Conclusions and Significance: PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data.
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