Related references
Note: Only part of the references are listed.Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases
Dimitri Krainc
ARCHIVES OF NEUROLOGY (2010)
High-throughput screening and small animal models, where are we?
Jean Giacomotto et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Strategies for the Inhibition of Protein Aggregation in Human Diseases
Manuela Bartolini et al.
CHEMBIOCHEM (2010)
Molecular Mechanisms of Rhodopsin Retinitis Pigmentosa and the Efficacy of Pharmacological Rescue
Mark P. Krebs et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Protein aggregation diseases: pathogenicity and therapeutic perspectives
Adriano Aguzzi et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
An Autophagy-Enhancing Drug Promotes Degradation of Mutant α1-Antitrypsin Z and Reduces Hepatic Fibrosis
Tunda Hidvegi et al.
SCIENCE (2010)
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Jason Rihel et al.
SCIENCE (2010)
High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model
Terence I. Moy et al.
ACS CHEMICAL BIOLOGY (2009)
Cdc25B Dual-Specificity Phosphatase Inhibitors Identified in a High-Throughput Screen of the NIH Compound Library
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2009)
ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters
Paul Gleeson et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Novel trends in high-throughput screening
Lorenz M. Mayr et al.
CURRENT OPINION IN PHARMACOLOGY (2009)
HTS and hit finding in academia - from chemical genomics to drug discovery
Julie A. Frearson et al.
DRUG DISCOVERY TODAY (2009)
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Gabriela Molina et al.
NATURE CHEMICAL BIOLOGY (2009)
Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay
Ikechukwu Okoli et al.
PLOS ONE (2009)
Modeling Molecular and Cellular Aspects of Human Disease Using the Nematode Caenorhabditis elegans
Gary A. Silverman et al.
PEDIATRIC RESEARCH (2009)
Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2008)
Caenorhabditis elegans as a model for lysosomal storage disorders
Gert de Voer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)
Molecular and cellular aspects of protein misfolding and disease
Eszter Herczenik et al.
FASEB JOURNAL (2008)
Generation of a set of simple, interpretable ADMET rules of thumb
M. Paul Gleeson
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
NATURE CHEMICAL BIOLOGY (2008)
Adapting proteostasis for disease intervention
William E. Balch et al.
SCIENCE (2008)
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B. Yui et al.
NATURE CHEMICAL BIOLOGY (2008)
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish
T. Cameron Tran et al.
CANCER RESEARCH (2007)
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2007)
Small molecule regulators of autophagy identified by an image-based high-throughput screen
Lihong Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
An antidepressant that extends lifespan in adult Caenorhabditis elegans
Michael Petrascheck et al.
NATURE (2007)
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury
Cliff J. Luke et al.
CELL (2007)
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
Trista E. North et al.
NATURE (2007)
Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2007)
Antifungal chemical compounds identified using a C-elegans pathogenicity assay
Julia Breger et al.
PLOS PATHOGENS (2007)
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
Chanhee Kang et al.
GENES & DEVELOPMENT (2007)
C-elegans models of age-associated neurodegenerative diseases:: Lessons from transgenic worm models of Alzheimer's disease
Christopher D. Link
EXPERIMENTAL GERONTOLOGY (2006)
High-content screening moves to the front of the line
Steven A. Haney et al.
DRUG DISCOVERY TODAY (2006)
Opposing activities protect against age-onset proteotoxicity
Ehud Cohen et al.
SCIENCE (2006)
A small-molecule screen in C-elegans yields a new calcium channel antagonist
TCY Kwok et al.
NATURE (2006)
Finding function in novel targets:: C-elegans as a model organism
T Kaletta et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Intracellular inclusions containing mutant α1-antitrypsin Z are propagated in the absence of autophagic activity
T Kamimoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Statistical practice in high-throughput screening data analysis
N Malo et al.
NATURE BIOTECHNOLOGY (2006)
Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance
DC Royal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Autophagy in metazoans: Cell survival in the land of plenty
JJ Lum et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Molecular mousetraps and the serpinopathies
DA Lomas et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans
BR Ellerbrock et al.
JOURNAL OF BIOMOLECULAR SCREENING (2004)
Improved statistical methods for hit selection in high-throughput screening
C Brideau et al.
JOURNAL OF BIOMOLECULAR SCREENING (2003)
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span
K Nehrke
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
An automated high-throughput assay for survival of the nematode Caenorhabditis elegans
MS Gill et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Autophagy genes are essential for dauer development and life-span extension in C-elegans
A Meléndez et al.
SCIENCE (2003)
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
BC Kraemer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein
M Lakso et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Hit and lead generation:: Beyond high-throughput screening
KH Bleicher et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
The NHX family of Na+-H+ exchangers in Caenorhabditis elegans
K Nehrke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
JF Morley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Cellular platforms for HTS: three case studies
PA Johnston et al.
DRUG DISCOVERY TODAY (2002)
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
T Oeda et al.
HUMAN MOLECULAR GENETICS (2001)
ADMET - turning chemicals into drugs
J Hodgson
NATURE BIOTECHNOLOGY (2001)
Chemical genetics: Ligand-based discovery of gene function
BR Stockwell
NATURE REVIEWS GENETICS (2000)
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells
NP Dantuma et al.
NATURE BIOTECHNOLOGY (2000)
Share Paper
