Journal
PLOS ONE
Volume 3, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0001542
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Funding
- Environmental Molecular Sciences Laboratory
- Department of Energy's Office of Biological and Environmental Research, Pacific Northwest National Laboratory [ER63232-1018220-0007203]
- National Institute of Allergy and Infectious Diseases
- NIH/DHHS [Y1-AI-4894-01]
- NIH National Center for Research Resources [RR18522]
- DOE [DE-AC05-76RLO 1830]
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While comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry, experimental validation of the existence of this core genome requires extensive measurement and is typically not undertaken. Enabled by an extensive proteome database developed over six years, we have experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. Although genomic studies can establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits.
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